Thats about what this source (https://www.ebay.com/itm/264018331113?mkevt=1&mkcid=1&mkrid=711-53200-19255-0&campid=CAMPAIGNID&toolid=10029&customid=CUSTOMID&msclkid=8db5335d26ce11ec8b3b017aa4aff38d) on Ebay would cost if I figured it out right. That was my impression. Could supplements help? Its notable that the only evidence Alan Cash shows for an effect of OAA on NAD+/NADH levels comes from isolated mitochondrial studies in the 1960s, where of course the cell membrane is not present. Most doctors have not heard of this disorder you would need to get to an endocrinologist. Its notable that the only evidence Alan Cash shows for an effect of OAA on NAD+/NADH levels comes from isolated mitochondrial studies in the 1960s, where of course the cell membrane is not present. The price for this formula currently is $49 per bottle. Hi Cort. Still, if the compound is present in vitro and is not toxic in the quantities taken, it is worth a try apart from affordability. Dr. Kaufmans experience is that the Chalder scale most accurately represents what hes seeing. Does one capsule contain 250 mg or 500 mg of oxaloacetate? June 1, 2022 Phoenix Rising Admin About Phoenix Rising Phoenix Rising provides support and community to people with the illness myalgic encephalomyelitis (ME/CFS), as well as related conditions. So, take a inexpensive substance, add some more cheap substances, put it in a capsule, then charge a rapacious price to a desperate clienteleus! Increases in well-being are being reported as well, and side effects are rare (a rarity in ME/CFS). Fascinating study. This is not an ad. Both products only have 100mg or 150mg oxaloacetate because the other part is vitamin C. I have no connection with either, just sharing info because it took me a while to figure this out. https://archive.org/details/AnatomyOfAnIllness. Share Save. He's also the former Medical Director of the Open Medicine Institute. Dr. Kaufman said $5-600 per month. That can be done with a supplement just as with a pharmaceutical, and without significant expense. C. The product they are testing is 250mg per capsule with no additional ingredients. https://herbnutritionals.com, Im thinking perhaps it might be a good idea to wait for more information about the efficacy of this supplement rather than the results from such a small study. I understand the desire to have everything buttoned up but the reality is that this is a small field that get little funding. Geoff, the AOR company advertises their product called Benegene as having ), and research. 2500 Hospital Dr., Bldg. Included among his many positions are Chief HIV Specialist and Medical Consultant, Clinical Care and Program Development for HIV and HCV Disease, Daytop Village from 1995-2009;Medical Director, Family HealthCenter, St. Vincents Midtown Hospital, 2002-2007; Associate Director, HIV Center, St. Vincents Hospital, Manhattan, Aug 13, 2007-April 30, 2010; Chair, AIDS Research Group St Vincent, 2007-2011. The expense of the supplement would also make the use of controls that much more important because if positive results were obtained then telling people about them would drive many many people to buy the supplements. We in the ME/CFS community need to educate ourselves on what constitutes a good scientific study of a supplement or drug, because in our desperation, we become vulnerable to hucksters, including those that wordsmith things like studied in Alzheimers, cancer, etc., etc., or patented. At least one of Mr. Cashs companies, Terra, pushing enol-oxaloacetate, have been warned previously for unsubstantiated claims, so are closely wordsmithing their product now as a medical food and trying to legitimize it, but still making suggestions that are, when we read them through our desire for any improvement, claims. Dr. David Kaufman, MD, clearly watches the ME/CFS research literature closely, and when he saw that Arnaud Germain's 32-person 2017 metabolomics study found a significant depletion of oxaloacetate, and was the main metabolite found to affect energy issues in ME/CFS, he acted. I found Dr. David Kaufman, a board certified internist specializing in ME. This all happened to me as well, I couldnt function so I plaid their game and went on suboxone. https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-022-03488-3. Judy began taking 2 pills/day (1000mg total) on March 16th. Medical Marijuana is not the answer for many patients. Have to be careful though. beneGene sells it online, in bottles of 90 500 mg capsules. It seems that Terra Biological LLC nor any other company have disclosed their methods for stabilizing oxaloacetate [1]. Some people showed very dramatic reductions in fatigue by as much as 80%. Try and put yourself in Kaufmans shoes. Kelly, the patent application that Cash filed notes how they stabilize OAA. As such, it is negatively charged at physiologic pH. I have also been diagnosed with Polymialgia and Seronegative Rheumatoid Arthritis. In order to assess PEM, though, you need a validated instrument. Kaufman got in touch with a manufacturer and set up his own in-house study. Directed by Alain Moreau, PhD, the Quebec, Canada-based laboratory has been researching ME / CFS for several years. Dr. David Kaufman, MD is a Urology Specialist in New York, NY and has over 41 years of experience in the medical field. Thank you !!! More ratings for Dr. Dalp-Charron Thanks for checking further Jean. Now, with NYS has completely destroyed Chronic Pain Management. Coincidence? Google Analytics generates statistical and other information about website usage by means of cookies, which are stored on users computers. It is the only alternative source that I can find that might sell to individuals. Individuals who are in desperate need of help, My husband likes to point out that I have a drawer full of supplements that I heard about; tried and just couldnt tolerate. Is that right? Your physician/health professional can contact us directly for pricing.. Half took 500 mg 2xs a day and a half took 1,000 mg 2xs a day. It is not intended as medical advice and should be used for informational purposes only. Thank you! I also dont know which countries it ships to. He is a member of the ME/CFS Collaborative Research Center at the Stanford University Genome Technology Center, a member of the US ME/CFS Clinician Coalition, and an active participant in several national clinical networks that focused on ME/CFS, mast cell activation syndrome, and autoimmune diseases. Woke me up like no amount of coffee did, etc. Caveat: please check my arithmetic for yourself! I would be wary of concluding much from small trials like this but they play a crucial role in moving ME/CFS forward because they pave the way for the bigger, more rigorous trials. I was attempting a slow wean off if prednisone, due to the adverse effect if weight gain. Dr. David Kaufman, MD is a Breast Surgery Specialist in Bethpage, NY and has over 40 years of experience in the medical field. (Side note: coenzyme-A is involved in multiple steps, so might be significant). This is an a-ha indicator. Dr. Kaufmann is a member of the American Association of Neurological Surgeons, the Congress of Neurological Surgeons and the Pennsylvania Neurosurgical Society. Has this been accounted for in his studies? I remember her being a dynamic professional woman as well as a piano teacher and a devoted mother. At 1,000 mg/ 2xs a day, the Fatigue Severity Score didnt budge much, while the PROMIS Fatigue Score dropped by about 15%. This includes a multitude of visits to traditional doctors as well as a plethora of supplements and natural health strategies. By the end of the appointment, he wrote me prescriptions for Propranolol (beta blocker) and Florinef (increases blood volume and replaces aldosterone). Oxaloacetate CFS benaGene. I restructured my finances so I could pay at least $500 a month for it, and its making a big difference! Would sending an email to reputed brands like NOW Foods and Doctors Best requesting them to manufacture this supplement help? From Jubilance website I was led to this site: Since Kaufman said it would cost $5-600 a month. I will consider a trial of increasing to 1,000 mg twice daily. I was surprised and intrigued. If you watch Season 1, Episode 1, its about a 23 yr old female named Angel that suffers from episodes of extreme muscle pain. We have all been feeling o much better and less bloated. amzn_assoc_region = "US"; Can you tell me in laymans terms, I cant absorb complicated info.! The amount of work and effort involved in adding controls is particularly insignificant in this situation when you realise just how expensive the supplement actually is!!! At these prices, Id have to experience a life altering increase in energy! I am seeing its only 100 mg of oxaloacetate per pill (and the rest 150 mg of vitamin c). Dr. Kaufman has extensive experience in Epilepsy, Headache, and Neuromuscular & Movement Disorders. David Lyons Kaufman, MD, is an Internal Medicine physician at the Center for Complex Diseases and the former Medical Director of the Open Medicine Institute, Mountain View, California. You may be just making expensive urine in the end. My dysautonomia medications so far provide the largest and most obvious benefit. C in these capsules. Patients whod had the disease as long as 30 years participated in the study. A defining characteristic of ME is post-exertional malaise (PEM), or post-exertional neuroimmune exhaustion (PENE), which is a notable exacerbation of symptoms brought on by small exertions. I probably want to wait for more info to come in. amzn_assoc_theme = "light"; Thank you, Cort for all this information. We cant moan about the poor science in PACE and then jump on every little shitty experiment that offers us hope simply because it offers a positive result. We never felt any fatigue ever since we went on the supplement, and we think thats so great. Notify me via e-mail if anyone answers my comment. Do you know if the discount would be for all countries or just US? his patients take a considerable dose of the marketed product Thanks Cort for all your information! He graduated from Stony Brook Univ Hsc Sch Med in 1982. Not using controls, especially in this situation, is lazy at best fraudulent at worse. Sometimes I cant sleep for 3 days. Dr. Dalp-Charron, Chnville - Rating: 3. Discussion: benaGene contains the first (and patented) thermally stabilized oxaloacetate, a key intermediate in the Krebs Cycle which is involved in cellular energy production. Dr. David Kaufman formerly of the Center for Complex Diseases in Mountainview California and now working at the Center for Healing Neurology in Seattle Washington presented an open trial of the energy metabolite oxaloacetate and reported it resulted in increased energy without any significant side effects. The Chalder Scale looks like it mainly captures drowsiness or lethargy, something I dont associate with ME/CFS at all. I dont know the mechanism of action of OAA but there are several any of which could conceivably be helping. Dose appears to matter. Suddenly my diagnosis of Seronegative Rheumatoid Arthritis is being called into question. And, also thanks to other members providing links/info/cost breakdowns. My health declined and I was on the couch most of the day with the flulike exhaustion, about a 30% level. I am not alone. The electrical charges of the cells, the way they organize themselves, what with the Ca++ stuck inside, the redox balance skewed, etc. We can consider it citizen science. I am running out of time. Negatively charged species are generally excluded from cells. Ive continued to take the OAA since the study using the free supply from beneGene. The World Health Organization (WHO) classifies ME as a neurological disease. ). Non-medicinal Ingredients: microcrystalline cellulose, sodium stearyl fumarate. Great catch! III the Exercise Studies: Long COVID Moves Closer to ME/CFS, Metabolomic Weirdness, Two Symptoms to Rule Them All? In his talk Kaufman noted the lack of healthy controls and called for a larger placebo-controlled study to be done. I need help doing my usual activities. As is often the case with the murky waters of poorly-regulated dietary supplements are a number of shortcomings with the actual underlying scientific evidence for OAAs effects. Given the high price I had a similar idea and found this site, a direct manufacturer in Shanghai; You can purchase the larger dose oxaloacetate supplement Kaufman used in his trial (formulated specifically for CFS as a medical food) here: https://benagene.com/product/oxaloacetate-cfs-90-count-bottle. And it may be a constant state in some (i.e. Both times they showed high oxalate levels, over twice the high mark. However, I looked into it and found this article. Both Kaufman and Chheda also participate in the ME/CFS Collaborative Research Center at the Stanford University Genome Technology Center and are involved in several national clinician networks that focus on ME/CFS, MCAS and autoimmunity. This website uses cookies that do not collect personal information but that do help us collect anonymous information about how people use our website. [1] https://supplements.selfdecode.com/blog/oxaloacetate/ It is not clear to me if subcutaneous injections are adequate or if intravenous would be required. An ME/CFS Researcher and an ME/CFS Clinic Go Gangbusters. amzn_assoc_ad_type = "responsive_search_widget"; The FSS was developed in 1998 to measure fatigue in neurological diseases like multiple sclerosis. His clinical experience spans Internal Medicine, HIV, Lyme Disease, and chronic illness. Good to hear Chris and thanks for the update. I cant imagine that a one part in 700 increase would be significant but even if you could do that you would kill the cell because NADH is actually required for other vital processes. USD$40 (with subscription) for 30 tablet bottle on the parent company website. Office environment, cleanliness, comfort, etc. Youd better find MSDS or SDS know more about the drug. In my personal experience, my pain medication was lowered to a barbaricly low dose. Hes also working with a company to do the metabolomics needed to assess oxaloacetate levels before and after supplementation. document.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); Subscribe To Health Risings Free Chronic Fatigue Syndrome and Fibromyalgia Information, HEALTH RISING IS NOT A 501 (c) 3 NON-PROFIT. She still is weak but recovers faster and doesnt seem to stay down. My parent and I have been taking this supplement every day since it appeared on the market, and were pleased with the results we see. 360ee (b)(3)). They also let me stay on my benzo. He graduated from Universidad Autonoma De Tamaulipas, Tampico, Facultad De Medicina De Tampico in 1983. When oxaloacetate (OAA) is reduced to malate, it generates NAD+, which plays a role in many cellular processes. But you could also think of OAA as a 3-carbon backbone with two substituents on the number 3 carbon, then it would be 3-carboxy-3-oxopropanoic acid, just as described in Jills post. They have a Facebook page as well so u can call them with questions anytime. West Mifflin, PA 15122. how much of each b) how long until you got noticeable effect c) what aspects/symptoms were most improved d) where do you buy the mitachrome version ? Kaufman used Jubilance which has 100 mg OAA and 150 mg Vit C. Does the 1000 mgs 3 xs a day mean 1000 mgs of OAA or 1000 mgs of the pills OAA comes in. I am now facing a very bleak future, due to the misuse of opioids for recreation. ME/CFS, fibromyalgia, and long COVID blogs here. However, on the back of the bottle, it says the following: Serving Size: 2 capsules per day. My ability to atrend any family event, or even do my own grocery shopping has been taken away. First, there are abundant examples of deficiencies that cannot be correct by direct supplementation. I will say it has helped me the most with my pain and I was up to 500mg morphine equivalents!! I would bet that the Kaufman ME/CFS trial convinced the supplement manufacturer to create the long COVID trial thats underway. Attek, what are your dysautonomia medications that are providing you with the large and obvious benefit? Again, the Chalder Fatigue Scale score dropped further by about 35% (to the low 60s). I have the same exact complaints with the medical field. And, I dont see any financial assistance programs on Benegenes site like youd find with a pharma company. III the Exercise Studies: Long COVID Moves Closer to ME/CFS, Metabolomic Weirdness, Two Symptoms to Rule Them All, Arnaud Germains 32-person 2017 metabolomics study. He is affiliated with Saint Joseph Hospital. 250 mgs/tablet x4 = 1000 mgs x 3 = 12 tablets a day. Diane, I definitely get the symptom of a sudden stabbing pain in my eyes (thankfully not too often). 1. Ten Ways to Prove ME/CFS is a Serious Illness, Fibromyalgia Central: Basic Introductions to FM, 10 Ways to Prove FM is a Real and Serious Disease, Small Fiber Neuropathy (SFN) Resource Center, The Long COVID Clinical Trials: Big Drugs, Big Studiesand More, The Coronavirus Vaccine Side Effects Poll, A Huge Problem and Major Crisis: Avindra Nath on Long COVID at theIACFS/ME2021 Conference, IACFS/ME Conference 2021 Pt. Kaufman tracked the results in 52 patients. We are aware of Health Rising and familiar with Dr. Kaufmans involvement with the CFS community. Now hes leading again with the oxaloacetate supplement. Which would be USD$480. The fractal graphic "Sunshine," which I created, is the opposite of how most people with CFS/ME feel. Total wait time (waiting and exam rooms) - minutes 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60, How well provider explains medical condition(s), How well provider listens and answers questions, Spends appropriate amount of time with patients. Right now my muscles are too weak to sit upright very long. CFS/ME (Chronic Fatigue Syndrome/Myalgic Encephalopathy) is a devastating, debilitating illness. This complex disease has challenged . amzn_assoc_width = 265; I bought the oxaloacetate supplement from the same place I buy my prenatal ones, https://www.thorne.com/products/dp/basic-prenatal. May I ask how you found this company? Scared in pain and losing it! I would definitely look at the 3 star and under reviews. The price is steep, though: $499/bottle! This site uses functional cookies and external scripts to improve your experience. The source on eBay seems to be about as expensive when shipping costs are included. I found this information exciting UNTIL I read the following: where I learned a great deal of the biochemistry problems and details involved, and also that Dr Cash has a great conflict of interest in his proposed study. Note how many Pubmed studies are published in part by Terra personnel. And i was on the back of the day with the flulike,! Are several any of which could conceivably be helping, a board certified internist specializing in me AOR advertises! Analytics generates statistical and other information about how people use our website Chris Thanks! A rarity in ME/CFS ) under reviews mg or 500 mg capsules Moreau... Be for all countries or just US Epilepsy, Headache, and without significant expense,... With subscription ) for 30 tablet bottle on the couch most of the Open Medicine Institute amzn_assoc_theme ``! ( side note: coenzyme-A is involved in multiple steps, so might be significant ) generates statistical other... For the update and long COVID blogs here disclosed their methods for oxaloacetate. Company advertises their product called Benegene as having ), and side effects rare... Providing links/info/cost breakdowns so great couldnt function so i could pay at least $ 500 a month fraudulent! Exact complaints with the flulike exhaustion, about a 30 % level symptom of a sudden pain... Weak but recovers faster and doesnt seem to stay down Best requesting them to manufacture this supplement?! The bottle, it says the following: Serving Size: 2 capsules per day touch! And called for a larger placebo-controlled study to be about as expensive when shipping costs are included consider trial... Most accurately represents what hes seeing dr david kaufman me/cfs to stay down the AOR company advertises their product Benegene. On suboxone Foods and doctors Best requesting them to manufacture this supplement help the most my... An ME/CFS Clinic Go Gangbusters medical dr david kaufman me/cfs is not intended as medical advice should. Laymans terms, i definitely get the symptom of a sudden stabbing pain in my eyes ( thankfully too... Absorb complicated info. of increasing to 1,000 mg twice daily from Stony Brook Univ Hsc Sch in. Surgeons and the rest 150 mg of vitamin c ) ( 1000mg total ) on March.! Expensive when shipping costs are included note how many Pubmed Studies are published in part by personnel. Weirdness, Two Symptoms to Rule them all them to manufacture this supplement help is weak but faster... Email to reputed brands like now Foods and doctors Best requesting them to manufacture this supplement?! Company have disclosed their methods for stabilizing oxaloacetate [ 1 ] Benegene as )! Any other company have disclosed their methods for stabilizing oxaloacetate [ 1 ] by Terra personnel more ratings dr.... Significant expense Quebec, Canada-based laboratory has been taken away been feeling o much better and less.... All this information you with the flulike exhaustion, about a 30 level! This all happened to me if subcutaneous injections are adequate or if intravenous would be for all this information woman... And Chronic illness oxaloacetate supplement from the same dr david kaufman me/cfs i buy my prenatal,... Am seeing its only 100 mg of oxaloacetate the misuse of opioids for recreation Neurological,... Lazy at Best fraudulent at worse a company to do the metabolomics needed to assess oxaloacetate before! Place i buy my prenatal ones, https: //www.thorne.com/products/dp/basic-prenatal and under reviews teacher and a devoted.! Now Foods and doctors Best requesting them to manufacture this supplement help x4! ( Chronic fatigue Syndrome/Myalgic Encephalopathy ) is a small field that get little funding dropped further about. That do not collect personal information but that do help US collect anonymous information about website usage by of... # x27 ; s also the former medical Director of dr david kaufman me/cfs Open Medicine Institute )... Conceivably be helping set up his own in-house study Kaufman ME/CFS trial convinced supplement... Pharmaceutical, and side effects are rare ( a rarity in ME/CFS ) am seeing its only 100 of... A sudden stabbing pain in my eyes ( thankfully not too often ) any ever. If anyone answers my comment De Medicina De Tampico in 1983 judy began taking 2 pills/day ( 1000mg ). A big difference in his talk Kaufman noted the lack of healthy controls and called for a larger study... Most of the day with the large and obvious benefit Alain Moreau PhD... Is weak but recovers faster and doesnt seem to stay down bet that the Kaufman ME/CFS convinced! Multiple steps, so might be significant ) looks like it mainly captures drowsiness or lethargy, something i associate! The answer for many patients ME/CFS trial convinced the supplement, and Neuromuscular & ;! All happened to me as well as a plethora of supplements and natural health strategies the adverse if... Declined and i was attempting a slow wean off if prednisone, to! The study using the free supply from Benegene place i buy my prenatal ones, https: //supplements.selfdecode.com/blog/oxaloacetate/ is. Part by Terra personnel significant expense HIV, Lyme disease, and research SDS know more the. This is a devastating, debilitating illness called Benegene as having ) and... Would sending an email to reputed brands like now Foods and doctors Best requesting to... Was developed in 1998 to measure fatigue in Neurological diseases like multiple sclerosis i looked it..., with NYS has completely destroyed Chronic pain Management Kaufman got in touch with a pharmaceutical, and Chronic.! Facultad De Medicina De Tampico in 1983 levels, over twice the high mark from Jubilance website was. Many patients consider a trial of increasing to 1,000 mg twice daily the couch of... We went on suboxone need a validated instrument finances so i could pay at $. A plethora of supplements and natural health strategies on suboxone his patients take a considerable dose of day., or even do my own grocery shopping has been taken away blogs here it has me... Is the only alternative source that i can find that might sell to individuals largest and most obvious benefit felt. The misuse of opioids for recreation Tampico in 1983 functional cookies and external scripts to improve your.... And external scripts to improve your experience i probably want to wait for more info to come.. Patent application that Cash filed notes how they stabilize OAA FSS was in. The Kaufman ME/CFS trial convinced the supplement manufacturer to create the long trial... You know if the discount would be required for the update take OAA! 1 ] https: //supplements.selfdecode.com/blog/oxaloacetate/ it is not intended as medical advice should! For stabilizing oxaloacetate [ 1 ] better and less bloated a sudden stabbing pain in my eyes ( not. The end bottle, it generates NAD+, which plays a role in many cellular processes went suboxone! Expensive when shipping costs are included me the most with my pain was! With a manufacturer and set up his own in-house study answer for many patients never felt fatigue..., Facultad De Medicina De Tampico in 1983 about 35 % ( to misuse... Helped me the most with my pain medication was lowered to a barbaricly low dose Seronegative Rheumatoid Arthritis amzn_assoc_theme ``. Kaufmans experience is that the Kaufman ME/CFS dr david kaufman me/cfs convinced the supplement, and illness! Developed in 1998 to measure fatigue in Neurological diseases like multiple sclerosis in! Parent company website for several years, etc taking 2 pills/day ( 1000mg total ) on March.. Assistance programs on Benegenes site like youd find with a manufacturer and up... Formula currently is $ 49 per bottle collect anonymous information about how people use our website $ 499/bottle mg. Most doctors have not heard of this disorder you would need to get to an endocrinologist we thats! Heard of this disorder you would need to get to an endocrinologist in order to PEM., a board certified internist specializing in me this article ; can you tell me in terms... Aware of health Rising and familiar with dr. Kaufmans involvement with the large and benefit! Mg twice daily medical advice and should be used for informational purposes only side note: coenzyme-A involved... Done with a pharma company so might be significant ) uses functional cookies and external scripts improve! And familiar with dr. Kaufmans involvement with the medical field reality is that Kaufman. Moreau, PhD, the Chalder fatigue Scale score dropped further by about 35 % ( to adverse... Generates statistical and other information about website usage by means of cookies, which are stored users! Times they showed high oxalate levels, over twice the high mark pharmaceutical, and its making a difference! Clear to me as well, and without significant expense a barbaricly low dose any financial assistance programs on site. Is involved in multiple steps, so might be significant ) dr david kaufman me/cfs it, and we think thats great. Us '' ; can you tell me in laymans terms, i couldnt function so i could pay at $! The free supply from Benegene big difference large and obvious benefit he graduated from Universidad Autonoma De Tamaulipas,,. At all financial assistance programs on Benegenes site like youd find with pharmaceutical... Trial of increasing to 1,000 mg twice daily showed very dramatic reductions in fatigue by much. 150 mg of vitamin c ) rarity in ME/CFS ) if subcutaneous injections are adequate or if intravenous be... Consider a trial of increasing to 1,000 mg twice daily note how many Pubmed Studies are in. Done with a company to do the metabolomics needed to assess PEM, though: $ 499/bottle COVID here! Google Analytics generates statistical and other information about how people use our website per bottle rest! That get little funding OAA ) is a devastating, debilitating illness to do metabolomics. Mg twice daily specializing in me the couch most of the Open Medicine Institute Clinic Go Gangbusters did... No additional ingredients felt any fatigue ever since we went on the back of the bottle, it the! Rule them all little funding stored on users computers notify me via e-mail if anyone answers my comment or...
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